Production of Cationic Nanogels with Potential Use in Controlled Drug Delivery
- 21 October 2013
- journal article
- research article
- Published by Wiley in Particle & Particle Systems Characterization
- Vol. 31 (1) , 101-109
Abstract
Dual‐stimuli‐responsive nanogel particles based on poly(2‐(diethylamino)ethyl) methacrylate (PDEAEMA) cross‐linked with ethylene glycol dimethacrylate (EGDMA) are prepared via batch emulsion polymerization. An in‐depth study of their swelling behavior is carried out, which presents a dual‐dependent thermo‐ and pH‐sensitivity tunable with the ionic strength. The study reveals that nanogel particles undergo a unique transition from a swollen state to a collapsed state at physiological conditions. Such systems presenting tunable sensitivity and synthesized using biocompatible components could be suitable for applications in the field of controlled drug or gene delivery.Keywords
Funding Information
- Spanish Plan Nacional de Materiales (MAT2012-36270-C04-01)
- Department of Education, Language Policy and Culture of the Basque government (BFI-2011-20)
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