Novel Resistance Mechanisms Including L1196Q, P1094H, and R1248_D1249 Insertion in Three Patients With NSCLC After ALK Tyrosine Kinase Inhibitor Treatment
Authors:
- 1 March 2021
- journal article
- research article
- Published by Elsevier in Journal of Thoracic Oncology
- Vol. 16 (3) , 477-482
Abstract
No abstract availableKeywords
Funding Information
- Taiho Pharmaceutical
- Center for Information Technology
- Chugai Pharmaceutical
- Bristol-Myers Squibb
- Clovis Oncology
- Pfizer
- Kissei
- Astellas Pharma
- Merck Sharp and Dohme United Kingdom
- AbbVie
- Dainippon Sumitomo Pharma
- Takeda Pharmaceutical Company
- Kyowa Kirin
- Janssen Pharmaceutica
- University of Tokyo
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science (18K06594)
- Novartis
- Ministry of Education, Culture, Sports, Science and Technology
- AstraZeneca
This publication has 12 references indexed in Scilit:
- Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistanceEBioMedicine, 2019
- Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 studyThe Lancet Oncology, 2018
- Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung CancerCancer Discovery, 2018
- Drug resistance in anaplastic lymphoma kinase‐rearranged lung cancerCancer Science, 2018
- The Effect of Conformational Flexibility on Binding Free Energy Estimation between Kinases and Their InhibitorsJournal of Chemical Information and Modeling, 2016
- Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors inALK-Rearranged Lung CancerCancer Discovery, 2016
- Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALKJournal of Clinical Oncology, 2009
- Massively parallel computation of absolute binding free energy with well-equilibrated statesPhysical Review E, 2009
- Identification of Novel Isoforms of theEML4-ALKTransforming Gene in Non–Small Cell Lung CancerCancer Research, 2008
- Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancerNature, 2007