Chemistry of the mycalamides: antiviral and antitumour compounds from a New Zealand marine sponge. Part 6.1–3 The synthesis and testing of analogues of the C(7)–C(10) fragment

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Abstract
The key structural features associated with the potent cytotoxicity observed in the mycalamide, onnamide, pederin and theopederin series have been defined on the basis of structure–activity studies. A model pharmacophore structure has been proposed and selected examples, with modest bioactivity, synthesized.