Failure of Assay to Identify Low Cobalamin Concentrations
Authors:
Open Access
- 1 December 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 46 (12) , 2017-2018
Abstract
We wish to report a serious problem in the ADVIA:Centaur® chemiluminescence assay for cobalamin (Bayer Diagnostics; formerly the ACS:Centaur® assay, Chiron Diagnostics). The problem is urgent for two reasons: (a) our findings suggest that many cobalamin-deficient patients are being missed; and (b) the assay is used by increasing numbers of laboratories, which some time ago abandoned radioisotopic methods and were recently faced with the withdrawal of widely used assays by Abbott Laboratories.Keywords
This publication has 2 references indexed in Scilit:
- Current Concepts in Cobalamin DeficiencyAnnual Review of Medicine, 2000
- The frequently low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalitiesEuropean Journal of Haematology, 1995