Expert Diagnosis of Plus Disease in Retinopathy of Prematurity From Computer-Based Image Analysis

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Abstract
Retinopathy of prematurity (ROP) is a vasoproliferative disease affecting premature infants. Since the 1980s, clinical diagnosis has been standardized using the International Classification for Retinopathy of Prematurity (ICROP).1,2 Diagnostic cut points identifying severe ROP requiring treatment have been proposed and tested.3 As a result of multicenter clinical trials, it is known that severe ROP may be successfully treated if it is diagnosed early.3,4 Furthermore, in spite of these advances in diagnosis and treatment, ROP continues to be a leading cause of childhood blindness worldwide.5,6

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