Is There Long-term Signal Intensity Increase in the Central Nervous System on T1-weighted Images after MR Imaging with the Hepatospecific Contrast Agent Gadoxetic Acid? A Cross-sectional Study in 91 Patients
Authors:
- 1 March 2017
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 282 (3) , 708-716
Abstract
Analysis of dose dependence showed a significantly positive correlation between signal intensity increase in the dentate nucleus and the number of previous gadoxetic acid administrations. PurposeTo evaluate whether there is T1-weighted signal intensity (SI) increase in the dentate nucleus (DN) and globus pallidus (GP) in relation to the middle cerebellar peduncle (MCP), pons, and thalamus after repeated administration of the liver-specific contrast agent gadoxetic acid.Materials and MethodsThis was an institutional review board–approved, prospectively conducted (written informed consent acquired), cross-sectional study performed in a consecutively selected patient group (n = 91; patients received one to 37 doses of gadoxetic acid) and a control group (n = 52; subjects had never received injections of gadolinium-based contrast agent) examined with a standard T1-weighted two-dimensional spin-echo pulse sequence of the brain at 1.5 T. DN/MCP, DN-to-pons, GP-to thalamus, and GP-to–cerebrospinal fluid ratios were measured and compared by using the nonparametric Kruskal-Wallis test, corresponding pairwise tests, and Spearman correlation.ResultsDN/MCP (ρ = 0.51, P < .0001) and DN-to-pons (ρ = 0.4...Keywords
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