IMMUNOLOGICAL RECOVERY AFTER MEASLES

Authors:
  • AWA Wesley
    A Wesley
  • HCH M Coovadia
    H M Coovadia
  • LHL Henderson
    L Henderson
Google Scholar
  • 1 January 1978
    • journal article
    • research article
Abstract
Children (22) with measles were studied at the stage of the rash and 6 wk later, and the results were compared with matched controls. The total lymphocyte count and lymphocyte subpopulations with T[thymus-derived]- and B[bone marrow-derived]-cell markers and those with absence of both markers (null cells) were significantly below control levels in the acute phase. At 6 wk the B cell and null cell counts were still significantly diminished. The function of T cells assessed by 14C uptake of phytohemagglutinin-stimulated lymphocytes and the delayed skin hypersensitivity reaction to dinitrochlorobenzene was impaired during the acute stage, and this persisted for 6 wk. Over the 6 wk of study there was a small but significant rise in serum Ig[immunoglobulin]G, IgM and complement factors.

This publication has 22 references indexed in Scilit: