Correlation of nonsense sites in the lacI gene with specific codons in the nucleotide sequence
Authors:
- Jeffrey H. MillerJMJeffrey H. Miller
- Christine CoulondreCCChristine Coulondre
- Philip J. FarabaughPFPhilip J. Farabaugh
- 1 August 1978
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 274 (5673) , 770-775
Abstract
Nonsense mutations derived from 90 different codons in the lacI gene of Escherichia coli were correlated with the I gene nucleotide sequence. In over 80 cases the specific codon which generates the nonsense mutation can be identified. The sequence shows that 14-16 sites arise through tandem double base changes.Keywords
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