Astrogliosis in ALS: possible interpretations according to pathogenetic hypotheses
- 1 March 2004
- journal article
- research article
- Published by Taylor & Francis in Amyotrophic Lateral Sclerosis
- Vol. 5 (1) , 22-25
Abstract
Literature findings on astrogliosis of the spinal cord and of the cortex of sporadic (SALS) and familial (FALS) cases of amyotrophic lateral sclerosis (ALS) and of SOD1 transgenic mice are analysed and compared with those of 50 autopsied personal cases of ALS. In the spinal cord, astrogliosis is definitely evident in the anterior horns and much less in anterior and lateral funiculi and dorsal horns. In the cortex reactive astrocytes show a distribution similar to that of ageing brains and in ischaemia and cannot be directly put in relation with neuronal loss. In the spinal cord of transgenic mice the evidence suggests a primary astrocytic response. The findings in human ALS, especially those of the cortex, are consistent with this hypothesis.Keywords
This publication has 23 references indexed in Scilit:
- Glial Cells of the Spinal Cord and Subcortical White Matter Up-regulate Neuronal Nitric Oxide Synthase in Sporadic Amyotrophic Lateral SclerosisExperimental Neurology, 2001
- Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of GlutamateNeuron, 1996
- Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosisAnnals of Neurology, 1995
- Ubiquitinated dystrophic neurites suggest corticospinal derangement in patients with amyotrophic lateral sclerosisNeuroscience Letters, 1994
- Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosisJournal of Neuroscience Research, 1994
- Neurofilament and glial alterations in the cerebral cortex in amyotrophic lateral sclerosisActa Neuropathologica, 1992
- A unique pattern of astrocytosis in the primary motor area in amyotrophic lateral sclerosisActa Neuropathologica, 1991
- Reactive Astrogliosis is Widespread in the Subcortical White Matter of Amyotrophic Lateral Sclerosis BrainJournal of Neuropathology & Experimental Neurology, 1991
- Corticofugal projections to the motor nuclei of the brainstem and spinal cord in humansNeurology, 1990
- A distinctive distribution of reactive astroglia in the precentral cortex in amyotrophic lateral sclerosisActa Neuropathologica, 1987