Inositol Deficiency Resulting in Death: An Explanation of Its Occurrence in Neurospora crassa

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Abstract
The incorporation of radioactive inositol and choline into the cytoplasmzic membranes of inositol- and choline-auxotrophic mutants of Neurospora crassa revealed that the membrane of particles which contain proteases is relatively poor in lecithin and rich in inositol-phospholipid. In mycelia of the mutant requiring inositol, grown in a suboptimum amount of exogenous inositol, the structural integrity of the protease particles is lost, and the bulk of intracellular protease activity is recovered in the soluble fraction of the cell. Death from this kind of inositol deficiency is interpreted as autolysis of the cytoplasm caused by free proteases.

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