N-Heterocyclic carbene catalyzed enantioselective [5 + 1] annulation to access indole-fused spirocycles: remote δ-carbon activation
- 1 January 2026
- journal article
- Published by Royal Society of Chemistry (RSC) in Organic Chemistry Frontiers
- Vol. 13 (17) , 5652-5657
Abstract
Herein, we report the NHC-catalyzed enantioselective [5 + 1] annulation between indole-derived α,β-γ,δ-unsaturated aldehydes and 3-aminomaleimides, providing a variety of enantiomerically enriched indole-based spirocycles in excellent yields.Keywords
Funding Information
- Natural Science Foundation of Hebei Province (B2023201062)
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