Does Reversal of Ischemia on Diffusion‐Weighted Imaging Reflect Higher Apparent Diffusion Coefficient Values?

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Abstract
This study investigated whether ischemia on diffusion‐weighted imaging (DWI) that reverses has higher apparent diffusion coefficients (ADCs). A patient treated with thrombolytics was evaluated with serial magnetic resonance imaging studies before treatment, at 3 and 14 days and at 4 weeks. A 100.01‐cm3left frontoparietal stroke on baseline DWI was only 18.11 cm3(18%) on 4‐week fluid attenuated inversion recovery. The mean ADC was 7.43 × 10−3mm2/s in the 6 regions that reversed and 7.31 × 10−3mm2/s in the 6 regions that persisted (P < .036). With thrombolytic treatment, large ischemic lesions on DWI may reverse, and these areas display higher mean ADCs.

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