Ring up the curtain on DING proteins
Authors:
- François BernierFBFrançois Bernier
- Ken ScottKSKen Scott
- Bruno StuhlmüllerBSBruno Stuhlmüller
- 12 July 2002
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 524 (1-3) , 6-10
Abstract
DING proteins have a characteristic DINGGG‐ or closely related N‐terminal sequence. One is found in human synovial fluid, and may be associated with rheumatoid arthritis. Other examples have receptor or signalling roles in various human and animal cells, or are involved in biomineralisation, and several of them bind to phytochemicals. As plant DING proteins have recently been discovered, we hypothesise that the DING protein‐phytochemical association may represent one aspect of a ubiquitous receptor‐linked signalling system. Several microbial proteins related to DING proteins have phosphatase activity, which may relate to biomineralisation in eukaryotic systems. Plant DING proteins and their microbial relatives may elicit allergic responses leading to arthritic disease.Keywords
This publication has 35 references indexed in Scilit:
- Two isoforms of a nucleotide‐sugar pyrophosphatase/phosphodiesterase from barley leaves (Hordeum vulgare L.) are distinct oligomers of HvGLP1, a germin‐like proteinFEBS Letters, 2001
- Effects of Tobacco Products on the Attachment and Growth of Periodontal Ligament FibroblastsJournal of Periodontology, 1999
- Cell-Mediated Crystallization of Calcium Oxalate in PlantsThe Plant Cell, 1999
- ECM signalling: orchestrating cell behaviour and misbehaviourTrends in Cell Biology, 1998
- Genistein‐induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cellsNutrition and Cancer, 1998
- Cigarette smoking and rheumatoid arthritis severityAnnals of the Rheumatic Diseases, 1997
- Nicotine and cotinine stimulate secretion of basic fibroblast growth factor and affect expression of matrix metalloproteinases in cultured human smooth muscle cellsJournal of Vascular Surgery, 1996
- Pleckstrin's repeat performance: a novel domain in G-protein signaling?Trends in Biochemical Sciences, 1996
- Augmented humoral and anaphylactic responses in FcγRII-deficient miceNature, 1996
- Synovial fluid pyrophosphate and nucleoside triphosphate pyrophosphatase: comparison between normal and diseased and between inflamed and non-inflamed joints.Annals of the Rheumatic Diseases, 1991