Evidence of Apoptosis in Arrhythmogenic Right Ventricular Dysplasia

Authors:
  • ATAlain Tedgui
    Alain Tedgui
  • FFFabrice Fontaliran
    Fabrice Fontaliran
  • RFRobert Frank
    Robert Frank
  • MDMichel Durigon
    Michel Durigon
  • GFGuy Fontaine
    Guy Fontaine

Abstract
Arrhythmogenic right ventricular dysplasia, a disorder that may lead to severe ventricular arrhythmias and sudden death, is characterized by the progressive replacement of myocardial cells by fat and fibrous tissue. We examined whether the loss of myocardial cells in this disease could result from cell death by apoptosis (programmed cell death).