Determination of parabens in pharmaceutical and cosmetic products by capillary electrophoresis
Authors:
- 1 October 2008
- journal article
- Published by Pleiades Publishing Ltd in Journal of Analytical Chemistry
- Vol. 63 (10) , 982-986
Abstract
A validated capillary electrophoresis method for the determination of parabens-methyl, ethyl, propyl, and butyl is described. The optimum results were obtained by the use of a run buffer containing 20 mM borate buffer (pH 9.0) with 10% methanol and by applying a voltage of 20 kV, a low hydrodynamic injection of 10 s, and detecting the signals at 200 nm. Moxifloxazin was used as an internal standard. All parabens were separated within 10 min. The method showed a good repeatability, linearity, and sensitivity. It was applied to the determination of parabens in pharmaceutical and certain cosmetic products.Keywords
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