Copper catalysis in the construction of indole and benzo[b]furan rings
Authors:
- 2 December 2010
- journal article
- perspective
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 9 (3) , 641-652
Abstract
This perspective reports on some of the main copper-catalyzed routes to the construction of the pyrrole and furan rings incorporated into the indole and benzo[b]furan systems, respectively. The first part illustrates the synthesis of indoles through cyclizations of 2-alkynylanilid(n)es, preformed or generated in situ, and cyclizationsvia intramolecular N-arylation, N-vinylation, and C–C bond forming reactions. The second part illustrates the synthesis of benzo[b]furans through cyclizations of preformed 2-alkynylphenols, domino synthesis of 2-alkynylphenols/cyclization processes, and cyclizationsvia intramolecular O-arylation reactions.Keywords
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