Use of fibrin film as a carrier for drug delivery: A long-acting delivery system for pilocarpine into the eye.

Authors:
  • SMShozo Miyazaki
    Shozo Miyazaki
  • KIKuniaki Ishii
    Kuniaki Ishii
  • MTMasahiko Takada
    Masahiko Takada
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Abstract
Fibrin film was evaluated as a new carrier for a long-acting delivery system for pilocarpine. The release characteristics of the pilocarpine-fibrin film system were investigated in in vitro and in vivo test models. The results indicated that the use of the pilocarpinefibrin film system is more effective than that of the conventional liquid dosage form for prolonging the duration of a desirable pupillary response. Its good biocompatibility, flexibility, and heat processability suggest the material to be a good candidate system for pilocarpine delivery into the eye.
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