Regulation of macrophage-mediated larvicidal activity inEchinococcus granulosusandMesocestoides corti(Cestoda) infection in mice

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SUMMARY: Killing of metacestodes by normal or post-infection macrophages and the regulation of this activity by cytokines were studied invitro. The protoscolecidal activity of normal macrophages againstEchinococcus granulosuswas inhibited by a product of naive T-enriched lymphocytes co-cultured with protoscoleces (PSC). By contrast, supernates from co-cultures ofMesocestoides cortitetrathyridia (MCT) and T-enriched or B-enriched normal lymphocytes increased killing of MCT by normal macrophages. Larvicidal activity (against both PSC and MCT) was enhanced by high concentrations of macrophage-activating factors produced by Con A-stimulated rat lymphocytes (Con A-LK), but was reduced by low concentrations of these factors.

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