Anti-inflammatory and antioxidative effects of leaf extract from Acanthopanax trifoliatus

Authors:
  • PSP Sithisarn
    P Sithisarn
  • SJS Jarikasem
    S Jarikasem
  • KTK Thisayakorn
    K Thisayakorn
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Abstract
Acanthopanax trifoliatus is a Thai plant belonging to the ginseng family or Araliaceae, which has been traditionally used for the treatment of oxidative-stress related diseases such as lung hemorrhages, bruises, ulcers, partial paralysis, and neurosis [1–2]. Its leaves are also popularly consumed as tonic vegetables. Our recent work has shown that the decoction extract from the leaves of A. trifoliatus significantly exhibited in vitro antioxidant activity determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay and thiobarbituric acid reactive substances (TBARS) method for lipid peroxidation of rat brain homogenate [3]. From our previous finding, we evaluated its ability to inhibit inflammation using carrageenan-induced rat paw edema model [4]. Two hours after inflammatory induction, A. trifoliatus leaf extract showed inhibitory effect in dose-dependent manner. At the dose of 600mg/kg, the extract exhibited a significant anti-inflammation (41% inhibition, PPO-caffeolylquinic acid and 4,5-di-O-caffeoylquinic acid which have been reported to exhibit antioxidant and anti-inflammatory activities [5–12]. Acknowledgements: The Graduate Program Development under the Collaboration between Thailand Institute of Scientific and Technological Research and Universities. References: [1] Perry, L.M. and Metzger, J. (1981) Medicinal Plant of East and Southeast of Asia. MIT Press. London. [2] Loi, D.T. (2000) Glossary of Vietnamese Medical Plants. S and T Pub. Ha Noi. [3] Sithisarn, P. and Jarikasem, J. (2009) Med. Prin. Pract. (accepted). [4] Winter, W.D. et al. (1987)J. Pharmacol. Exp. Ther. 244:51–57. [5] Yonathan, M. et al. (2006)J. Ethnopharmacol. 108:462–470. [6] Jung, H.A. et al. (1999) Arch. Pharm. Res. 22:213–218. [7] Kozlov, A.B. et al. (1994) Biochem. Pharmacol. 47:795–799. [8] Guardia, T. et al. (2001) Il Farmaco 56:683–687. [9] Nakajima, Y. et al. (2007) Life Sci. 80:370–377. [10] Peluso, G. (1995)J. Nat. Prod. 58:639–646. [11] Wagner, C. et al. (2006) Brain Res. 1107:192–198. [12] Camuesco, D. et al. (2004) Br. J. Pharmacol. 143:908–918.