Contribution of Asymmetric Synapse Loss to Lateralizing Clinical Deficits in Frontotemporal Dementias
Authors:
- C. Munro CullumCCC. Munro Cullum
- Sivapong SatumtiraSSSivapong Satumtira
- Estelle SontagESEstelle Sontag
- Linda S. HynanLHLinda S. Hynan
- Charles L. White IiiCICharles L. White Iii
- Eileen H. BigioEBEileen H. Bigio
Open Access
- 1 August 2001
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 58 (8) , 1233-1239
Abstract
SYNAPSE LOSS in Alzheimer disease (AD) was initially reported in 19871 and was first correlated with cognitive decline in 1990.2 In a 1991 landmark study by Terry and colleagues,3 synapse loss was found to be the major correlate of cognitive impairment in AD. This has subsequently been confirmed by a number of studies.4-8Keywords
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