Mechanochemical Rh(I)-Catalyzed C–N/C–C/C–H Triple Bond Activation of Amides

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Abstract
Direct decarbonylative triple C-N, C-C, and C-H functionalization of amides with hydrocarbons has been accomplished under mechanochemical conditions via Rh(I) catalysis. This method exhibits excellent substrate versatility in high-yielding couplings with diverse aromatic compounds, and its utility is highlighted by late-stage pharmaceutical derivatization and orthogonal C-X and C-N sequential cross-couplings. This solvent-free mechanochemical approach drastically lowers the temperature required for triple amide activation, overcoming kinetic barriers through a sustainable pathway.
Funding Information
  • Education Department of Shaanxi Province (22JC018)
  • National Natural Science Foundation of China (22179075)
  • National Natural Science Foundation of China (22373062)
  • National Institute of General Medical Sciences (R35GM133326)

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