INTRODUCTION AND AIMS: Peritoneal sclerosis is a rare and serious complication associated with peritoneal dialysis (PD), with difficult management, high morbidity and mortality. Diagnosis is suspected when digestive symptoms (such as nausea, vomiting or weight loss) and bowel habit alterations are present. Confirmation requires thickening of peritoneal membrane and encapsulation with either an abdominal CT or peritoneal biopsy. Treatment is mainly symptomatic, including analgesia and nutritional support. Steroids and tamoxifen are used to prevent fibrosis. In advanced cases, surgery may be necessary.