Protective effect of probiotics in the treatment of infantile eczema
Authors:
Open Access
- 17 February 2015
- journal article
- Published by Spandidos Publications in Experimental and Therapeutic Medicine
- Vol. 9 (5) , 1593-1596
Abstract
The aim of the present study was to provide evidence for the application of probiotics in the prevention and treatment of infantile eczema by exploring changes in the intestinal Bifidobacteria levels and the Scoring Atopic Dermatitis (SCORAD) index prior and subsequent to treatment with probiotics in infants with eczema. A total of 40 infants with eczema were randomly divided into treatment and control groups. Prior and subsequent to the treatment, the SCORAD index was evaluated and the content of Bifidobacterium bifidum in the stool of each infant in the two groups was quantified using 16S rRNA/DNA quantitative polymerase chain reaction analysis. After four weeks of treatment with B. bifidum triple viable capsules, the levels of B. bifidum increased sharply (P<0.05) and the SCORAD index was notably reduced (P0.05). Following treatment, the levels of B. bifidum in the stools of the treatment group were significantly higher than those in the stools of the control group (P<0.05), and the SCORAD index was significantly lower than that of the control group (P<0.05). In conclusion, probiotic supplementation has a positive effect on the prevention and treatment of infantile eczema.Keywords
This publication has 23 references indexed in Scilit:
- Asthma and frequency of wheeze: risk factors for the persistence of atopic dermatitis in childrenAnnals of Allergy, Asthma & Immunology, 2013
- Guidance on the diagnosis and clinical management of atopic eczemaClinical and Experimental Dermatology, 2012
- Low diversity of the gut microbiota in infants with atopic eczemaJournal of Allergy and Clinical Immunology, 2012
- Probiotic Therapy as a Novel Approach for Allergic DiseaseFrontiers in Pharmacology, 2012
- Probiotics and immune healthCurrent Opinion in Gastroenterology, 2011
- Japanese Guideline for Food AllergyAllergology International, 2011
- Any benefits of probiotics in allergic disorders?Allergy and Asthma Proceedings, 2010
- Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohortJournal of Allergy and Clinical Immunology, 2009
- A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of ageArchives of Disease in Childhood, 2006
- Bifidobacterial Species Differentially Affect Expression of Cell Surface Markers and Cytokines of Dendritic Cells Harvested from Cord BloodClinical and Vaccine Immunology, 2004