Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities

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Abstract
This study explores the antifungal properties of Agaricus blazei Murrill, a valuable medicinal and edible fungus. Six compounds (1–6) were first isolated from A. blazei using various isolation techniques and identified using spectroscopic methods. These compounds include linoleic acid, 1,1′-oxybis(2,4-di-tert-butylbenzene), glycerol monolinoleate, volemolide (17R)-17-methylincisterol, (24s)-ergosta-7-en-3-ol, and dibutyl phthalate. This study also assesses the antifungal activities of these compounds against Trichophyton mentagrophology, Trichophyton rubrum, Candida albicans, and Cryptococcus neoformans. The results demonstrate varied sensitivities against these pathogenic fungi, with compound 2 showing significant inhibition against T. mentagrophology, compound 3 showing significant inhibition against T. rubrum, and compound 6 showing significant inhibition against C. albicans. This study underscores the medicinal potential of A. blazei as an antifungal agent and sheds light on its valuable research implications.
Funding Information
  • Shenzhen Natural Science Fund (20220811110339002, JCYJ20190808122213241, 2019B1515120029, 81973293)
  • Shenzhen Science and Technology Innovation Committee (20220811110339002, JCYJ20190808122213241, 2019B1515120029, 81973293)
  • Guangdong Basic and Applied Basic Research Foundation (20220811110339002, JCYJ20190808122213241, 2019B1515120029, 81973293)
  • National Natural Science Foundation of China (20220811110339002, JCYJ20190808122213241, 2019B1515120029, 81973293)

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