Dietary fish oil–induced changes in the distribution ofα-tocopherol, retinol, andβ-carotene in plasma, red blood cells, and platelets: modulation by vitamin E

Authors:
  • JJJ T Judd
    J T Judd
  • EBE Berlin
    E Berlin
  • PTP R Taylor
    P R Taylor
  • SSS Shami
    S Shami
  • ESE Sainz
    E Sainz
  • HBH N Bhagavan
    H N Bhagavan
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Abstract
Healthy men (ages 24–57 y) were fed a controlled basal diet supplemented with 15 g/d of placebo oil (PO) for 10 wk followed by 15 g/d of fish-oil concentrate (FO) (fortified with 15 mg all-rac-tocopherol) for 10 wk without additional α-tocopherol and the last 8 wk with 200 mg α-tocopherol/d (FO + E). Compared with PO, FO raised plasma malondialdehyde; lowered α-tocopherol in plasma, red blood cells, and platelets; and raised plasma and platelet β-carotene. Supplementation with additional α-tocopherol (FO + E) not only restored tocopherol concentrations but also reversed the rise in β-carotene. The response in retinol, particularly in platelets, showed an inverse relationship to β-carotene, α-tocopherol exhibiting a modulating effect on these changes. From these observations it is postulated that platelets may be a significant extraintestinal site of retinol formation from β-carotene.

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