Calcium channels as pharmacological targets for cancer therapy

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Abstract
Ca2+, as critical second messengers in biological processes, plays a pivotal role in the regulation of diverse cellular signaling pathways. The dysregulation of calcium signaling is intricately linked to the progression of various cancers. The capacity of Ca2+ to modulate cell death and proliferation, along with its potential for pharmacological manipulation, presents a promising avenue for the development of novel cancer therapeutics. This review provides a comprehensive overview of the classification of Ca2+ channels and their mechanisms of action in oncogenesis, explores the application of Ca2+ blockers in cancer treatment, and underscores the importance of conducting further clinical trials.
Funding Information
  • Natural Science Foundation of Shandong Province (ZR2023QH113)
  • National Natural Science Foundation of China (82074093)
  • Medical Science and Technology Project of Zhejiang Province (2023RC140)
  • State Administration of Traditional Chinese Medicine Science and Technology Department- Zhejiang Provincial Administration of Traditional Chinese Medicine (GZY-ZJ-SY-2402)

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