Pharmacokinetic-Pharmacodynamic Modelling of Morphine Transport Across the Blood-Brain Barrier as a Cause of the Antinociceptive Effect Delay in Rats—A Microdialysis Study
Authors:
- 1 October 2000
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 17 (10) , 1220-1227
Abstract
Purpose. To quantify the contribution of distributional processes across the blood-brain barrier (BBB) to the delay in antinociceptive effect of morphine in rats. Methods. Unbound morphine...Keywords
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