Dermal and Transdermal Drug Delivery Systems

Authors:
  • KWKenneth A. Walters
    Kenneth A. Walters
  • MLMajella E. Lane
    Majella E. Lane
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Abstract
This chapter reviews progress in the development of dermal and transdermal delivery systems. Both dermal and transdermal drug therapy for local and systemic effect require the active agent to be delivered to the site of action. Skin permeation and enhancement technologies, together with delivery systems, have been the regular subject of updates and reviews, as have the differences between diseased and normal stratum corneum. It has been known for some time that permeation across the skin is controlled mainly by the tortuous but continuous intercellular lipid of the stratum corneum. The authors investigated the comparative skin permeation and found that the permeation of desogestrel was significantly greater than that of levonorgestrel. The intercellular lipid lamellae are highly structured, very stable and provide a highly effective barrier to chemical penetration and permeation. While permeation of ondansetron through pig skin from a base gel was low, the addition of isopropyl myristate or camphor improved delivery.

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