Antioxidant and antipyretic properties of methanolic extract of Amaranthus spinosus leaves

Authors:
  • BKBagepalli Srinivas Ashok Kumar
    Bagepalli Srinivas Ashok Kumar
  • KLKuruba Lakshman
    Kuruba Lakshman
  • KJKn Jayaveera
    Kn Jayaveera
  • DSDevangam Sheshadri Shekar
    Devangam Sheshadri Shekar
  • AKAvalakondarayappa Arun Kumar
    Avalakondarayappa Arun Kumar
  • BMBachappa Manoj
    Bachappa Manoj
Open Access
Publisher website
Google Scholar
Abstract
ObjectiveMethanolic extract of Amaranthus spinosus (A. spinosus) leaves was screened for antioxidant and antipyretic activities.MethodsAntioxidant activity was measured by 1,1-diphenyl-2-picryl-hydrazile (DPPH) free radical scavenging, superoxide anion radical scavenging, hydroxyl free radical scavenging, nitric oxide radical scavenging, 2,2 '-azinobis-3-ethylbenzothiazole-6-sulfonic acid (ABTS) radical scavenging assays and total phenolic content was also determined. Antipyretic activity of methanolic extract of A. spinosus was measured by yeast induced pyrexia method at concentration of 200 and 400 mg/kg using paracetamol as standard drug.ResultsMethanolic extract of A. spinosus showed potent antioxidant activity. The IC 50 value was (87.50 ±3.52) μg/mL, (98.80±1.40) μg/mL, (106.25±0.20) μg/mL, (88.70±0.62) μg/mL and (147.50±2.61) μg/mL for DPPH, superoxide, hydroxyl, nitric oxide and ABTS radical scavenging activities. Methanolic extract of A. spinosus showed significant (P <0.01) antipyretic activity

This publication has 19 references indexed in Scilit: