Increased Risk of Papillary Thyroid Cancer in Celiac Disease
- 7 September 2006
- journal article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 51 (10) , 1875-1877
Abstract
Patients with celiac disease have an increased rate of malignancies that are not limited to lymphomas. Thyroid carcinoma has not previously been associated with celiac disease. However, among a cohort of patients with celiac disease, we identified an increased risk of papillary carcinoma of the thyroid, standard morbidity ratio of 22.52 (95% confidence interval 14.90–34.04; P < .001), compared to United States national surveillance data. These patients were on a gluten-free diet. Only 1 had Hashimoto's thyroiditis, suggesting that mechanisms apart from autoimmune thyroiditis contribute to the increased risk of carcinoma of the thyroid in celiac disease.Keywords
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