GABAergic signalling to adult‐generated neurons
- 15 August 2008
- journal article
- review article
- Published by Wiley in The Journal of Physiology
- Vol. 586 (16) , 3745-3749
Abstract
New neurons are continuously generated in discrete regions of the adult brain. In the hippocampus, newly generated cells undergo a step‐wise progression of maturation that is regulated at multiple stages by a variety of physiological and pathological stimuli. Neural progenitors and newborn neurons initially receive exclusively GABAergic synaptic input, and accumulating evidence suggests that depolarizing actions of GABA contribute to activity‐dependent regulation. Here we provide a brief overview of GABAergic signalling to newborn neurons in the hippocampus and describe how it regulates adult neurogenesis.Keywords
This publication has 27 references indexed in Scilit:
- A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult BrainNeuron, 2007
- Paradoxical influence of hippocampal neurogenesis on working memoryProceedings of the National Academy of Sciences, 2007
- GABA sets the tempo for activity-dependent adult neurogenesisTrends in Neurosciences, 2007
- Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrusProceedings of the National Academy of Sciences, 2006
- Seizures Accelerate Functional Integration of Adult-Generated Granule CellsThe Journal of Neuroscience, 2006
- GABAergic Excitation Promotes Neuronal Differentiation in Adult Hippocampal Progenitor CellsNeuron, 2005
- Variations on an inhibitory theme: phasic and tonic activation of GABAA receptorsNature Reviews Neuroscience, 2005
- A Transgenic Marker for Newly Born Granule Cells in Dentate GyrusJournal of Neuroscience, 2004
- Is there more to gaba than synaptic inhibition?Nature Reviews Neuroscience, 2002
- GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesisNeuron, 1995