Overcoming wet tissue adhesion remains a persistent challenge in biomedicine due to interference from blood and tissue fluids, yet there is strong demand for biosafe, robust, and multifunctional surgical bioadhesives. We present a supramolecular adhesive network that integrates peptide coiled-coils with polyethylene glycol (PEG). In this system, coiled-coil motifs, formed in situ through zinc ion chelation, spatially organize amphiphilic residues to enable tissue adhesion via van der Waals forces and electrostatic interactions. In its dehydrated state, the adhesive network is non-adhesive but rapidly activates strong adhesion upon contact with wet tissues by absorbing interfacial water. The dehydrated coiled-coil-PEG patch achieves hemostasis and sealing of gastric punctures in both rat and porcine models, as well as effective irregularly shaped wound repair. Its dynamic coiled-coil architecture confers ultrafast self-healing (6000% strain), strong cohesion, and full recyclability. By covalently incorporating bioactive peptides and physically encapsulating nanomaterials, the adhesive system becomes multifunctional. Demonstrated biosafety, biocompatibility, and scalable fabrication underscore its clinical and industrial potential in tissue regeneration, hemostasis, and bio-integrated wearables—ushering in a new paradigm for managing complex tissue interfaces.