THE INHIBITORY EFFECT OF STROPHANTHIDIN ON SECRETION BY THE ISOLATED GASTRIC MUCOSA
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Open Access
- 20 July 1959
- journal article
- research article
- Published by Rockefeller University Press in Journal of General Physiology
- Vol. 42 (6) , 1233-1239
Abstract
The unidirectional fluxes of Na+ and Cl- were measured across the isolated gastric mucosa of the bullfrog (R. catesbiana). The addition of strophanthidin, a cardiac aglycone, resulted in marked reductions of the spontaneous potential and short-circuit current. Associated with these changes, the isolated gastric mucosa ceased secreting chloride and hydrogen ion. Although the active component of chloride transfer was inhibited, the exchange diffusion component seemed to increase. No significant changes in membrane conductance or sodium flux were noted.Keywords
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