Palladium-Catalyzed Dearomatization of Indoles with Alkynes: Construction of Spirocyclohexaneindolenines
- 20 July 2023
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 88 (15) , 11335-11345
Abstract
A palladium-catalyzed dearomatization of indoles withalkynes hasbeen developed, providing an efficient route to access a variety ofsynthetically useful spirocyclohexaneindolenines in moderate to goodyields. The current method features a simple catalytic system, operationalsimplicity, and good functional group compatibility, which will contributesubstantially to the development of dearomatization to access spirocompounds. Besides, the ubiquitous existence of spiro molecules, includingspirocyclohexaneindolenines, in drugs and biological active moleculessuggests the potential application of this methodology in medicinalchemistry.Keywords
Funding Information
- Jiangsu Ocean University (KYCX2022-05)
- Jiangsu Key Laboratory of Function Control Technology for Advanced Materials (jsklfctam202106)
- Natural Science Foundation of Jiangsu Higher Education Institution of China (21KJB150006)
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