Prognostic value of biochemical variables for survival after surgery for metastatic bone disease of the extremities

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Abstract
BACKGROUND AND OBJECTIVE:Prediction of survival in patients having surgery for metastatic bone disease in the extremities (MBDex) has been of interest in more than two decades. Hitherto no consensus on the value of biochemical variables has been achieved. Our purpose was (1) to investigate if standard biochemical variables have independent prognostic value for survival after surgery for MBDex and (2) to identify optimal prognostic cut off values for survival of biochemical variables.METHODS:In a consecutive cohort of 270 patients having surgery for MBDex, we measured preoperative biochemical variables: hemoglobin, alkaline phosphatase, C‐reactive protein and absolute, neutrophil and lymphocyte count. ROC curve analyses were performed to identify optimal cut off levels. Independent prognostic factors for variables were addressed with multiple Cox regression analyses.RESULTS:Optimal cut off levels were identified as: hemoglobin 7.45 mmol/L, absolute lymphocyte count 8.5 × 109/L, neutrophil 5.68 × 109/L, lymphocyte 1.37 × 109/L, C‐reactive protein 22.5 mg/L, and alkaline phosphatase 129 U/L. Regression analyses found alkaline phosphatase (HR 2.49) and neutrophil count (HR 2.49) to be independent prognostic factors.CONCLUSIONS:We found neutrophil count and alkaline phosphatase to be independent prognostic variables in predicting survival in patients after surgery for MBDex.
Funding Information
  • Capital Region of Denmark Research and Innovation Foundation
  • Center of Head and Orthopedics, Rigshospitalet
  • Board of Management, Rigshospitalet
  • Lykfeldt's Legat

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