Antioxidant Activity of Thio-Schiff Bases

Authors:
  • JSJuliana Santos
    Juliana Santos
  • RLRebeca Mol Lima
    Rebeca Mol Lima
  • TPThamiris Vilela Pereira
    Thamiris Vilela Pereira
  • ACAntonio Marcio Resende Do Carmo
    Antonio Marcio Resende Do Carmo
  • NRNadia Rezende Barbosa Raposo
    Nadia Rezende Barbosa Raposo
  • ASAdilson Silva
    Adilson Silva
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Abstract
This study evaluated and compares the antioxidant activity of six resveratrol analogues. The analogues 4’- Hydroxyphenyl-benzo[d]thiazole (A), p-(N,N-dimethyl)aminobenzylidene-2-aminothiophenol (B) and p-Nitrobenzylidene- 2-aminothiophenol (C) were synthesized and the antioxidant activity was evaluated using the DPPH method. A descriptive statistical analysis and ANOVA followed by the Tukey test, with the aid of software. The best antioxidant activity was demonstrated by compound C (half maximal inhibitory concentration (IC50) = 18.45µM), this compound is two times more active than resveratrol (IC50= 37.28µM). Taken together, the data presented herein suggest that these molecules might serve as potential antioxidant considering that molecular modification is an effective strategy. As such, the compounds described herein can serve as prototypes for further research and the development of novel antioxidant agents.