Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a randomized, double-blind, controlled trial

Authors:
  • AGA. I. M. Glen
    A. I. M. Glen
  • AJA. L. Johnson
    A. L. Johnson
  • MSM. Shepherd
    M. Shepherd
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Abstract
Synopsis: A detailed analysis of the results of a multi-centre clinical trial shows that, while the relapse rate following recovery from an operationally defined depressive illness was smaller among patients subsequently treated with either amitryptiline or lithium than with a placebo, there was no clinically significant difference between the prophylactic efficacy of the 2 antidepressants. An account is given of the relative adverse effects of the treatments, and the implications of the findings are discussed.

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