The Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways
Open Access
Abstract
Currently, the treatment of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) [HBV-HCC] relies on blunt tools that are unable to offer effective therapy for later stage pathogenesis. The potential of miRNA to treat HBV-HCC offer a more targeted approach to managing this lethal carcinoma; however, the complexity of miRNA as an ancillary regulator of the immune system remains poorly understood. This review examines the overlapping roles of HBx-dysregulated miRNA in HBV-HCC and immune pathways and seeks to demonstrate that specific miRNA response in immune cells is not independent of their expression in hepatocytes. This interplay between the two pathways may provide us with the possibility of using candidate miRNA to manipulate this interaction as a potential therapeutic option.Keywords
Funding Information
- National Institutes of Health (HHSN261200800001E)
- Russian Science Support Foundation (project 17- 14-01338)
This publication has 380 references indexed in Scilit:
- MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in miceeLife, 2013
- An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular OncogenesisCell, 2011
- Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 ResponsesCell, 2010
- Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosisBiomedicine & Pharmacotherapy, 2010
- RETRACTED: miR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 DownregulationCancer Cell, 2009
- Role of MicroRNA-155 at Early Stages of Hepatocarcinogenesis Induced by Choline-Deficient and Amino Acid–Defined Diet in C57BL/6 Mice†Hepatology, 2009
- miR-155 gene: A typical multifunctional microRNABiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
- MicroRNA Control in the Immune System: Basic PrinciplesCell, 2009
- Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA ClustersCell, 2008
- Altered Expression of miR-21, miR-31, miR-143 and miR-145 Is Related to Clinicopathologic Features of Colorectal CancerOncology, 2007