The Positive Effect of Pasteurized Akkermansia muciniphila on the Glycolipid Metabolism of Caenorhabditis elegans Induced by High Glucose Diet

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Abstract
Glycolipid metabolism is essential for maintaining metabolic homeostasis. As a new generation of probiotics, Akkermansia muciniphila is important for the regulation of immunity and metabolism. This study aimed to evaluate the effects of pasteurized Akkermansia muciniphila (P-AKK) on glycolipid metabolism in Caenorhabditis elegans fed a high glucose diet. We discovered that feeding nematodes P-AKK improved their healthy lifespan when fed a high-glucose diet. Furthermore, P-AKK contributes to reducing the accumulation of glucose and lipids and maintains a better physiological state. In addition, P-AKK improved the composition of free fatty acids and decreased the total fatty acid content of C. elegans. Transcriptome sequencing analysis revealed that P-AKK activated the β-oxidation of fatty acids while inhibiting the de novo synthesis of fatty acids to regulate glycolipid metabolism. The administration of P-AKK positively affected the body phenotypes of C. elegans under high glucose conditions. P-AKK mitigated the fat accumulation induced by a high-glucose diet by regulating key metabolic enzymes, including acyl-CoA synthetase and stearoyl-CoA desaturase.
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