BH3-Only Proteins and BH3 Mimetics Induce Autophagy by Competitively Disrupting the Interaction between Beclin 1 and Bcl-2/Bcl-XL

Authors:
  • ETEzgi Tasdemir
    Ezgi Tasdemir
  • JVJosé Miguel Vicencio
    José Miguel Vicencio
  • NTNicolas Tajeddine
    Nicolas Tajeddine
  • JHJohn A. Hickman
    John A. Hickman
  • OGOlivier Geneste
    Olivier Geneste
  • GKGuido Kroemer
    Guido Kroemer
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Abstract
Beclin 1 has recently been identified as novel BH3-only protein, meaning that it carries one Bcl-2-homology-3 (BH3) domain. As other BH3-only proteins, Beclin 1 interacts with anti-apoptotic multid...