The interaction of aflatoxins with purines and purine nucleosides
Authors:
- Ji CliffordJCJi Clifford
- Kr ReesKRKr Rees
- 1 May 1967
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 103 (2) , 467-471
Abstract
From measurements of thermal hyperchromicity and the behaviour of an aflatoxin-DNA mixture on a Sephadex column it was concluded that aflatoxin B1 is capable of weak binding to single-stranded DNA. The interactions of the aflatoxins (B1, G1 and G2) with nucleosides result in difference spectra and suggest that the purine bases and the amino group play a role in the binding of all the aflatoxins to DNA.Keywords
This publication has 9 references indexed in Scilit:
- The effect of the aflatoxins B1, G1, and G2 on protein and nucleic acid synthesis in rat liverBiochemical Journal, 1967
- Action de l'aflatoxine sur le métabolisme du DNA au cours de l'hypertrophie compensatrice du foie après hepatectomie partielleBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
- Aflatoxin B 1 : Binding to DNA in vitro and Alteration of RNA Metabolism in vivoScience, 1966
- Aflatoxin: a Site of Action in the Rat Liver CellNature, 1966
- [Early nucleolar lesions induced by aflatoxin in rat hepatic cells].1965
- ACTINOMYCIN D EFFECTS ON NUCLEIC ACID AND PROTEIN METABOLISM IN INTACT AND REGENERATING LIVER OF RATS1965
- ANTIMETABOLITES AFFECTING PROTEIN OR NUCLEIC ACID SYNTHESIS. PHLEOMYCIN, AN INHIBITOR OF DNA POLYMERASE.1964
- On the factors controlling the reversibility of DNA denaturationJournal of Molecular Biology, 1962
- Interaction of Actinomycin C with constituents of nucleic acidsBiochimica et Biophysica Acta, 1961