Osteonecrosis in children and adolescents with cancer

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Abstract
Osteonecrosis is recognized increasingly as a complication of the treatment of cancer in young people, especially those with acute lymphoblastic leukemia and non‐Hodgkin lymphoma, reflecting a probable pathogenetic role of steroid therapy. Children ≥10 years of age and Whites are at particular risk, and genetic predispositions have been identified. The disorder affects weight‐bearing joints predominantly. It is commonly bilateral and multi‐articular. Treatment options include both surgical and non‐surgical interventions. Pediatr Blood Cancer 2008;50:483–485.

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