Tricyclic 2′-C-Modified Nucleosides as Potential Anti-HCV Therapeutics
- 16 September 2010
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 12 (20) , 4466-4469
Abstract
Promising biological activity in a number of therapeutic areas has been reported for both tricyclic nucleosides and 2′-modified nucleosides. In particular, disubstitution at the C-2′ position of nucleosides has resulted in significant activity against the hepatitis C virus (HCV). Combining this with the observation that tricyclic nucleosides developed in our laboratory have been shown to inhibit the RNA-dependent RNA polymerase NS5B led to the design of a series of 2′-modified tricyclic nucleosides. Details of the synthesis, structural characterization, and preliminary biological results are reported.Keywords
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