Periventricular Leukomalacia: Relationship between Lateral Ventricular Volume on Brain MR Images and Severity of Cognitive and Motor Impairment

Authors:
  • AHAlexander H. Hoon
    Alexander H. Hoon
  • JFJr Joseph T. Ferrucci
    Jr Joseph T. Ferrucci
  • CQCynthia B. Quinn
    Cynthia B. Quinn
  • ERElsie M. Reinhardt
    Elsie M. Reinhardt
  • SDSusan W. Demetrides
    Susan W. Demetrides
  • BFBethany M. Freeman
    Bethany M. Freeman
  • MJMichael V. Johnston
    Michael V. Johnston
Publisher website
Google Scholar
Abstract
PURPOSE: To evaluate the utility of lateral ventricular volume measurements in predicting motor and cognitive impairment severity in children with periventricular leukomalacia (PVL), with or without seizures. MATERIALS AND METHODS: The charts of children with spastic cerebral palsy and PVL documented on brain magnetic resonance (MR) images were reviewed. Affected children were grouped by motor and cognitive impairment severity and seizure disorder. An age-matched control group was established. Lateral ventricular volumes were measured on two-dimensional T2-weighted spin-echo MR images. Analysis of variance was used to identify significant differences in mean lateral ventricular volume between groups. Paired analyses of differences were performed with the Bonferroni t method. RESULTS: Thirty-six children (24 boys, 12 girls) with spastic cerebral palsy and PVL and 21 age-matched control subjects (14 boys, seven girls) were identified. Mean lateral ventricular volumes of the moderate and marked motor deficit...

This publication has 19 references indexed in Scilit: