Dopaminergic Terminals in the Rat Cortex
Authors:
- 2 November 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 182 (4111) , 499-501
Abstract
The destruction of ascending noradrenergic pathways by bilateral microinjections of 6-hydroxydopamine made laterally to the pedunculus cerebellaris superior completely abolished the in vitro synthesis of [ 3 H]norepinephrine from L-[ 3 H]tyrosine in slices and in synaptosomes of the rat cortex. However, normal [ 3 H]dopamine synthesis could still be observed in both cortical preparations from animals with lesions. These results provide the first biochemical support for the existence of dopaminergic terminals independent of noradrenergic terminals in the rat cortex.Keywords
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