Blockade of the Flush Associated with Metastatic Gastric Carcinoid by Combined Histamine H1and H2Receptor Antagonists
Authors:
- L. Jackson RobertsLRL. Jackson Roberts
- Samuel R. MarneySMSamuel R. Marney
- John A. OatesJOJohn A. Oates
- 1 February 1979
- journal article
- case report
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 300 (5) , 236-238
Abstract
THE circulating mediator (or mediators) responsible for flushing seen in patients with carcinoid syndrome has remained unidentified. The patient described in this study, a 54-year-old woman with a metastatic gastric carcinoid tumor, has experienced approximately four attacks of flushing a day for the past 22 years, each lasting for approximately 30 minutes to three hours.1 , 2 In 1962 this patient was studied by Oates and Sjoerdsma and found to have markedly elevated levels of urinary free histamine. Administration of L-histidine monohydrochloride markedly increased the frequency, severity and duration of flushes.1 , 2 Despite this evidence that histamine might participate in the flushing attacks, . . .Keywords
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