Reductive Umpolung Reactions with Low-Valent Titanium Catalysts
Author:
- 19 September 2014
- journal article
- research article
- Published by Wiley in The Chemical Record
- Vol. 14 (6) , 1100-1113
Abstract
The coupling of similarly polarized carbon fragments can be achieved by a reductive umpolung strategy. This gives access to compounds with functional groups in even bond distances, which are difficult to synthesize by other means. Low-valent titanium catalysts enable such couplings under mild conditions. This account covers the recent progress on this topic with a focus on the development of cross-selective coupling reactions and stereoselective examples.Keywords
This publication has 167 references indexed in Scilit:
- Convenient Titanium(III)‐Catalyzed Synthesis of Cyclic Aminoketones and Pyrrolidinones—Development of a Formal [4+1] CycloadditionAngewandte Chemie International Edition, 2013
- Replacing Conventional Carbon Nucleophiles with Electrophiles: Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and ChloridesJournal of the American Chemical Society, 2012
- Catalytic, Atom‐Economical Radical Arylation of EpoxidesAngewandte Chemie International Edition, 2012
- Palladium-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to Five-, Six-, and Seven-Membered β-Substituted Cyclic Enones: Enantioselective Construction of All-Carbon Quaternary StereocentersJournal of the American Chemical Society, 2011
- Pd–NHC Catalyzed Conjugate Addition versus the Mizoroki–Heck ReactionChemistry – A European Journal, 2011
- Samarium Diiodide Mediated Reactions in Total SynthesisAngewandte Chemie International Edition, 2009
- Enantioselective Synthesis of All‐Carbon Quaternary Stereogenic Centers by Catalytic Asymmetric Conjugate Additions of Alkyl and Aryl Aluminum Reagents to Five‐, Six‐, and Seven‐Membered‐Ring β‐Substituted Cyclic EnonesAngewandte Chemie International Edition, 2008
- Titanocene-Catalyzed Pinacol Couplings: Reagent-ControlledTransition-Metal-Catalyzed Radical ReactionsEuropean Journal of Organic Chemistry, 1998
- Enantioselective C-C and C-H Bond Formation Mediated or Catalyzed by Chiral ebthi Complexes of Titanium and ZirconiumAngewandte Chemie International Edition, 1996
- The Synthesis of 3,6-Disilyl-1,4-Cyclohexadienes by the Trapping of Benzene Anion-RadicalsJournal of the American Chemical Society, 1962