Oxetane Ring‐Opening Reaction: A Key Step for the Preparation of Substituted (Fluoro)alkenyl as Acyclonucleoside Mimics
Authors:
- 10 May 2023
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 26 (21)
Abstract
Tri‐ and tetra‐substituted alkenes, including fluoroalkenes, were prepared by a selective ring‐opening reaction of functionalized oxetanes. The introduction of adenine nucleic base allows the synthesis of alkenyl and fluoroalkenyl derivatives that were evaluated towards DltA enzyme as potential nucleoside mimics.Keywords
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