Systemic Lupus Erythematosus
Authors:
- Georgios PappasGeorgios Pappas
- Alessandro GranitoAlessandro Granito
- Francesco B BianchiFBFrancesco B Bianchi
- 29 May 2008
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 358 (22) , 2412-2413
Abstract
In their review article, Rahman and Isenberg (Feb. 28 issue)1 emphasize the role of anti–double-stranded DNA antibodies in the pathogenesis of systemic lupus erythematosus. Such antibodies also occur, however, in 23 to 64% of patients with type 1 autoimmune hepatitis, depending on the assay used.2 Interestingly, 36% of patients with type 1 autoimmune hepatitis and antibodies against double-stranded DNA have the HLA allele DR3, which is a genetic risk factor in both systemic lupus erythematosus and type 1 autoimmune hepatitis.3 However, there is no evidence of a pathogenic role of anti–double-stranded DNA antibodies in type 1 autoimmune hepatitis.Keywords
This publication has 11 references indexed in Scilit:
- Systemic Lupus ErythematosusNew England Journal of Medicine, 2008
- Fifty years of anti-ds DNA antibodies: are we approaching journey's end?Rheumatology, 2007
- Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosusJournal of Experimental Medicine, 2005
- IRF-7 is the master regulator of type-I interferon-dependent immune responsesNature, 2005
- Induction of interferon‐α production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgGArthritis & Rheumatism, 2004
- Autoantibodies in the Diagnosis and Management of Liver DiseaseJournal of Clinical Gastroenterology, 2003
- Plasmacytoid Dendritic Cells (Natural Interferon- α/β-Producing Cells) Accumulate in Cutaneous Lupus Erythematosus LesionsThe American Journal of Pathology, 2001
- The Nature of the Principal Type 1 Interferon-Producing Cells in Human BloodScience, 1999
- Human leukocyte antigen A1-B8-DR3-DQ2-DPB1*0401 extended haplotype in autoimmune hepatitisHepatology, 1993
- Antibodies to double-stranded (native) DNA in active chronic hepatitis.Gut, 1975