Rational design and synthesis of sulfonamide-substituted coumarinyl-imidazolone hybrids against multidrug-resistant microbial strains: computational and biological evaluation studies
- 24 September 2026
- journal article
- research article
- Published by Taylor & Francis in Future Medicinal Chemistry
- Vol. 18 (20) , 2877-2892
Abstract
1. The global rise of antimicrobial resistance (AMR), a phenomenon first highlighted over four decades ago by Stanley Falkow, has now escalated into one of the most formidable global health threats...Keywords
This publication has 38 references indexed in Scilit:
- Design, synthesis of next generation indomethacin-based cyclooxygenase-2 inhibitor: An in silico and in vitro investigationInternational Journal of Biological Macromolecules, 2025
- Synthesis and Antifungal Activity of Coumarin Derivatives Containing Hydrazone MoietyChemistry & Biodiversity, 2024
- Synthetic coumarin derivatives with anticoagulation and antiplatelet aggregation inhibitory effectsMedicinal Chemistry Research, 2023
- In-vitro anticancer evaluation of newly designed and characterized tri/tetra-substituted imidazole congeners- maternal embryonic leucine zipper kinase inhibitors: Molecular docking and MD simulation approachesInternational Journal of Biological Macromolecules, 2023
- In vitro and in silico antibacterial evaluation of coumarin derivatives against MDR strains of Staphylococcus aureus and Escherichia coliMicrobial Pathogenesis, 2023
- Recent investigation on heterocycles with one nitrogen [piperidine, pyridine and quinoline], two nitrogen [1,3,4-thiadiazole and pyrazole] and three nitrogen [1,2,4-triazole]: a reviewJournal of the Iranian Chemical Society, 2021
- Microwave-assisted synthesis of new 2-aryl and 2-alkylimidazolones and evaluation of their in vitro anticancer activity and their in vivo toxicity on zebrafish embryosChemical Papers, 2021
- New imidazolone derivatives comprising a benzoate or sulfonamide moiety as anti-inflammatory and antibacterial inhibitors: Design, synthesis, selective COX-2, DHFR and molecular-modeling studyBioorganic Chemistry, 2020
- Imidazole derivatives as antiparasitic agents and use of molecular modeling to investigate the structure–activity relationshipParasitology Research, 2020
- AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibilityJournal of Computational Chemistry, 2009